selectivity switchable catalyst for asymmetric cascade reactions
our project is at the forefront of innovation in the field of homogeneous catalysis. in the domain of supramolecular catalysis, non-covalent interactions are designed between the partners of the catalytic reaction in order to build catalysts with new functions or modify the catalytic performance of an existing catalyst.[1] we propose a new approach in which hydrogen-bonded supramolecular polymers, formed by means of non-covalent interactions between structurally-simple monomers, are used as a scaffold for catalysis. as a proof-of-concept, we performed asymmetric reactions by means of intrinsically achiral metal complexes positioned at the periphery of chiral assemblies. these chiral assemblies are formed by mixing chiral and achiral bta monomers.[2-7] the topic of this thesis concerns the use of selectivity switchable catalysts in stereoselective cascade reactions, following our recently published papers.
major publications in the domain:
[1] m. raynal, p. ballester, a. vidal-ferran, p. w. n. m. van leeuwen chem. soc. rev. 2014, 43, 1660
[2] a. desmarchelier, x. caumes, m. raynal, a. vidal-ferran, p. w. n. m. van leeuwen, l. bouteiller j. am. chem. soc. 2016, 138, 4908
[3] j. m. zimbron, x. caumes, y. li, c. m. thomas, m. raynal, l. bouteiller angew. chem. int. ed. 2017, 56, 14016
[4] y. li, x. caumes, m. raynal, l. bouteiller chem. commun. 2019, 55, 2162
[5] y. li, l. bouteiller, m. raynal chemcatchem 2019, 11, 5212
[6] m. martinez-aguirre, y. li, n. vanthuyne, l. bouteiller, m. raynal, angew. chem. int. ed., 10.1002/anie.202012457.
[7] y. li, a. hammoud, l. bouteiller, m. raynal, j. am. chem. soc., 2020, 142, 5676-5688