曼彻斯特大学（英国）PhD Position in Harnessing the nasal proteome for lung cancer early detection申请条件要求-申请方
主办方
曼彻斯特大学（英国）
PhD直招介绍
About the Project
Lung cancer causes more deaths than any other cancer because it is diagnosed late when there is no cure. Two landmark clinical trials have demonstrated CT screening scans saves lives by detecting lung cancer earlier when they can be cured. However, CT scans are expensive and involve a radiation exposure, limiting screening to those at the very highest risk and excluding 50-60% people who develop lung cancer. Current screening also requires healthcare contact, which can be a barrier for people living in areas of high deprivation, where lung cancer is most common but healthcare engagement lowest.
There is an urgent need for accessible, home-based tests for early lung cancer detection. We have discovered and validated a protein signature of lung cancer detectable in the nose using a simple swab that people can self-sample at home. This studentship will develop a scalable test using three complementary approaches: standard controlled mass spec, multiplex ELISA and emerging ELISA technologies such as Alamar Biosciences’ NULISA platform. The student will also determine whether these proteins can identify lung cancer before diagnosis by analysing a unique cohort of 700 people screened for lung cancer 7 years ago. Although all were cancer-free at sampling, 30-40 subsequently developed cancer. This work will advance a scalable, minimally invasive approach to earlier lung cancer detection, with the potential to extend screening to people currently excluded from CT-based programmes.
The final objective is to understand the mechanisms underlying these nasal protein changes using a novel in vitro platform we have developed. This model enables healthy bronchial epithelial cells to be transformed into cancer and co-cultured with nasal epithelial and immune cells from the same person. This will allow us to investigate how developing cancer alters the nasal environment and identify biological mechanisms driving the protein signature.
Equality, diversity and inclusion are central to the University’s activities. The full statement can be found here: https://www.bmh.manchester.ac.uk/study/research/getting-started/equality-diversity-inclusion/
References
1. Gracie K, Kennedy MPT, Esterbrook G, Smith G, Blaxill P, Ameri AT, Rodger KIA, Robson JM, Paramasivam E, Naseer R, Smith P, Ellames DAB, Hawramy B, Callister MEJ. The proportion of lung cancer patients attending UK lung cancer clinics who would have been eligible for low-dose CT screening. Eur Respir J. 2019;54(2). 10.1183/13993003.02221-2018
2. Team AS. Shared Gene Expression Alterations in Nasal and Bronchial Epithelium for Lung Cancer Detection. J Natl Cancer Inst. 2017;109(7). 10.1093/jnci/djw327
3. Hill W, Lim EL, Weeden CE, Lee C, Augustine M, Chen K, Kuan FC, Marongiu F, Evans EJ, Jr., Moore DA, Rodrigues FS, Pich O, Bakker B, Cha H, Myers R, van Maldegem F, Boumelha J, Veeriah S, Rowan A, Naceur-Lombardelli C, Karasaki T, Sivakumar M, De S, Caswell DR, Nagano A, Black JRM, Martinez-Ruiz C, Ryu MH, Huff RD, Li S, Fave MJ, Magness A, Suarez-Bonnet A, Priestnall SL, Luchtenborg M, Lavelle K, Pethick J, Hardy S, McRonald FE, Lin MH, Troccoli CI, Ghosh M, Miller YE, Merrick DT, Keith RL, Al Bakir M, Bailey C, Hill MS, Saal LH, Chen Y, George AM, Abbosh C, Kanu N, Lee SH, McGranahan N, Berg CD, Sasieni P, Houlston R, Turnbull C, Lam S, Awadalla P, Gronroos E, Downward J, Jacks T, Carlsten C, Malanchi I, Hackshaw A, Litchfield K, Consortium TR, DeGregori J, Jamal-Hanjani M, Swanton C. Lung adenocarcinoma promotion by air pollutants. Nature. 2023;616(7955):159-67. 10.1038/s41586-023-05874-3
4. Ogden J, Sellers R, Sahoo S, Oojageer A, Chaturvedi A, Dive C, Lopez-Garcia C. A novel human model to deconvolve cell-intrinsic phenotypes of genetically dysregulated pathways in lung squamous cell carcinoma. bioRxiv. 2023:2023.12.13.568969. 10.1101/2023.12.13.568969
曼彻斯特大学（英国） PhD Position in Harnessing the nasal proteome for lung cancer early detection项目有没有奖学金，是不是全奖Phd招生，下面我们一起看一下【大学名称】Phd的奖学金资助情况
项目资助情况
Funding Notes
The PhD component of the MB-PhD studentship is usually funded for three years, or four years in exceptional circumstances with prior agreement of CRUK MCRC MB-PhD Committee and supervisory team.
The studentship covers:
1. An annual stipend of £22,894 (2027-2028) per year to help with living costs
2. Full funding for your PhD tuition fees (at the UK rate, with fee bursaries available for high-performing EU/International candidates).
3. PhD project consumables and running costs, including costs for researcher development such as conferences and travel
4. Reimbursement of MBChB tuition fees (at the UK rate) for a maximum of four years
曼彻斯特大学（英国）Phd申请条件和要求都有哪些？PhD Position in Harnessing the nasal proteome for lung cancer early detection项目是不是全奖？有没有奖学金？下面我们一起看一下曼彻斯特大学（英国）申请Phd直招需要具备哪些条件和要求，以及托福、雅思语言成绩要到多少才能申请。
申请要求
Eligibility
To apply to intercalate onto the PhD in Cancer Sciences component of the MB-PhD, you must meet the below criteria and satisfy the general requirements for permission to intercalate set by your institution, including passing all components of the MBChB at first attempt in the year prior to intercalation.
A University of Manchester MBChB student
holding a BSc (hons) 2.1 or above in a relevant subject and in year 2 or year 3 of the MBChB or year 1 or year 2 of GEM; or
currently studying in year 3 of the MBChB or year 2 of GEM
A University of St Andrews Medicine BSc (Hons) student on the Manchester course pathway:
holding or predicted a BSc (hons) 2.1 or above and be intending to intercalate straight onto the MB-PhD ahead of your arrival in Manchester or by no later than between year 3 and year 4 of the Manchester MBChB programme
A University of Leeds MBChB student:
currently studying in year 3 of the MB ChB
International applicants (including EU nationals) must ensure they meet the relevant academic eligibility criteria( https://www.manchester.ac.uk/study/international/country-specific-information/ ) (including English Language).
报名方式
招生人信息
Prof T Hussell, Dr S Knight, Dr M Menon, Prof P Crosbie
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