About the Project
Project Summary
Dystonia causes disabling muscle contractions and abnormal postures. This PhD will use robotics (vBOT) and advanced brain imaging (EEG, OPM MEG) at Aston University to study how the brain plans and holds movement, in partnership with clinicians at Queen Elizabeth Hospital Birmingham.
Project Details
Dystonia is a movement disorder characterised by involuntary muscle contractions, twisting movements, and abnormal postures. The underlying brain mechanisms remain poorly understood. A recent breakthrough showed that the brain’s “hold” commands (which keep a limb still) are generated by integrating preceding movement commands (Albert et al., 2020, eLife). This project will test whether this “move‑to‑hold” integration is disrupted in dystonia.
The main experimental work will be conducted at Aston University, where you will use a vBOT robotic interface to precisely quantify movement and postural control, alongside EEG and OPM‑MEG (a wearable brain‑imaging technology) to measure neural activity during movement and holding tasks.
Participants with dystonia will be recruited through the Queen Elizabeth Hospital Birmingham movement disorders clinic, in collaboration with Dr Benjamin Wright and Dr Venkat Srinivasan.
What you will do:
Year 1: Establish the vBOT platform at Aston University; run experiments in healthy volunteers (EEG + vBOT); receive training in OPM‑MEG.
Year 2: Recruit patients with dystonia via QE Hospital; collect behavioural and neuroimaging data primarily at Aston University.
Year 3: Analyse data, test whether brain oscillations predict movement and holding behaviour, and prepare publications.
Why this matters:
First direct test of the integrator hypothesis in dystonia.
Potential identification of a new brain‑based biomarker (beta oscillations).
A 4‑month clinical placement at QE Hospital provides hands‑on experience in a world‑class neurology centre.
Training and placement: You will receive expert supervision from a multidisciplinary team spanning neuroscience, neuroimaging, and clinical neurology.
The project includes a 4‑month PhD+ clinical placement at Queen Elizabeth Hospital Birmingham, where you will work directly with movement‑disorders patients and clinicians, complementing your Aston‑based experimental research.
International applicants: International applicants are welcome and will not need to pay any difference between Home and Overseas tuition fees.