About the Project
This PhD, supported by Vertex, will develop a next-generation Glomerulus-on-a-Chip platform that integrates engineering design, microfluidics, mechanobiology and biomaterials to recreate the biomechanical and biochemical microenvironment of the human glomerulus. The project will incorporate advanced chip fabrication, tunable extracellular-matrix architectures, and physiologically relevant shear stress and flow-driven filtration, enabling quantitative control of disease-relevant mechanical cues. A key focus is engineering dynamic co-culture interfaces between podocytes, endothelial and mesangial cells with immune cells, allowing mechanotransduction and inflammatory signalling to be modelled in a controlled microengineered system.
The student will use sensor integration, live-cell imaging and computational readouts to characterise filtration, cytokine transport and matrix remodelling in real time. The model will be designed as a scalable and reproducible in-vitro technology using commercially derived primary cells to ensure robustness.
This technology-driven platform will be used to investigate how inflammatory and fibrotic processes affect glomerular barrier function and downstream tubular responses. Expected outcomes include a validated chip technology for studying kidney pathology and a mechanistic framework for personalising therapeutic testing.
This project is part of the EPSRC Centre for Doctoral Training in Next Generation Organ on a Chip Technology (COaCT)