曼彻斯特城市大学PhD Position in How do force sensing proteins contribute to the progression of liver fibrosis?申请条件要求-申请方
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曼彻斯特城市大学
PhD直招介绍
About the Project
Project advert
Chronic liver disease is associated with obesity and ageing, and results in liver fibrosis (scarring) which kills. As fibrosis progresses, the liver’s mechanical properties change, with an increase in tissue stiffness due to an excessive production of extracellular matrix (ECM) proteins made by pro-fibrotic cells. Different cell types of the liver such as hepatocytes and hepatic stellate cells are subjected to the increased tissue stiffness which has a negative impact on their normal function, driving fibrotic processes.
Cells respond to extracellular rigidity through a process called mechanotransduction where physical conditions outside a cell are converted into biochemical signals. Integrins are important cell-ECM receptors that have a role in mechanotransduction that work through the formation of a protein complex called the adhesome.
This project will use biochemical and cell biology approaches to study liver cell adhesomes and ask how cell-ECM mechanotransduction signalling contributes to liver fibrosis. Techniques used will include molecular biology, mammalian cell culture and transfection / transduction, qPCR, immunofluorescence staining and microscopy, western blotting, biochemical affinity-enrichment with proteomics sample preparation and bioinformatic data analyses.
The successful applicant will join our vibrant Doctoral College Community and be based in the new £117million Dalton Building in the heart of Manchester.
Project aims and objectives
This project will define the role of cell-ECM mechanotransduction and signalling in liver fibrosis. This will be achieved using biochemical and cell biology approaches to study the role of cell-ECM adhesion systems in relevant cell models of liver disease.
Our objectives are to:
1. Define hepatic stellate cell and hepatocyte adhesomes
2. Identify mechanosensory adhesome protein interactions in hepatic stellate cells and hepatocytes
曼彻斯特城市大学 PhD Position in How do force sensing proteins contribute to the progression of liver fibrosis?项目有没有奖学金，是不是全奖Phd招生，下面我们一起看一下【大学名称】Phd的奖学金资助情况
项目资助情况
The student will be in receipt of a stipend payment; the Research Council minimum rate (set by UKRI) £20,780 for 2025/26.
Home and Overseas students can apply. Home fees are covered. Eligible overseas students will need to make up the difference in tuition fee funding.
曼彻斯特城市大学Phd申请条件和要求都有哪些？PhD Position in How do force sensing proteins contribute to the progression of liver fibrosis?项目是不是全奖？有没有奖学金？下面我们一起看一下曼彻斯特城市大学申请Phd直招需要具备哪些条件和要求，以及托福、雅思语言成绩要到多少才能申请。
申请要求
The qualifications, skills, knowledge and experience applicants should have for this project, in addition to our standard entry requirements( https://www.mmu.ac.uk/study/postgraduate/research-study/phd/how-to-apply ).
The student will have undertaken a laboratory-based final year research project.
The student should have at least upper-second class honours in Biomedical Science or a related degree subject.
The student will have previous experience of relevant techniques such as molecular biology, mammalian cell culture and transfection/transduction, qPCR, immunofluorescence staining and microscopy, western blotting, biochemical affinity-enrichment with proteomics sample preparation and bioinformatic data analyses.
报名方式
申请链接
招生人信息
Jon Humphries
邮箱：j.humphries@mmu.ac.uk
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